It is extremely important that only scientifically based information can be posted on this website. We follow the most important guideline of modern medicine, "Evidence Based Medicine". With these professional materials, we would like to draw attention to the importance of morbidity in inflammatory processes.
The clinical significance of larval, cellular inflammation in our chronic, progressive diseases
Dr. Tamás Nagy - 17/07/2018
The association between adiposity, inflammation, and insulin resistance has become increasingly known since it was first described by Hotamisligil et al. In 1993 (30).
Adipose tissue produces a number of inflammatory mediators that contribute significantly to the chronic inflammatory condition and metabolic complications associated with obesity. It is a highly researched and well-documented process that can link seemingly distinct diseases. These include insulin resistance, hypothyroidism, depression, arthritis (inflammation of the joints), varicose veins (varicose veins), or PCOS (polycystic ovary syndrome).
These problems are usually treated separately by specialists in the field, although if the deep-seated disease process continues without intervention, a straight path to atherosclerosis, i.e. atherosclerosis, leads through the same pathomechanism.
Thus, it is no coincidence that every second of our compatriots loses their life in a cardiovascular disease. Given that 62,846 people died of this disease in Hungary in 2016 alone, according to the WHO European Mortality Database, the importance of a more detailed mapping of this disease process is not an exaggeration. It should be emphasized that the 45-59 age group is the most vulnerable.
The balance and homeostasis of cells and tissues has shifted due to today's modern environmental influences and nutrition. Researchers claim that persistent mild, latent inflammation at the cellular level plays a role in the development of many cardiovascular (cardiovascular), neurological (nervous), and cancerous diseases.
Cell damage caused by inflammatory cytokines circulating in the blood also triggers higher amounts of superoxides (free radicals) in the cell. The resulting "oxidative stress" further damages the cells and releases new inflammatory substances. This completes the "vicious circle" and triggers premature aging and the development of chronic diseases. Inflammation also contributes to the development of diabetes, obesity and insulin resistance. Indirectly, inflammation may be associated with effects on the immune system, depression, and other neurological diseases.
Inflammatory cytokines, mainly TNF (tumor necrosis factor system), IL-6 (interleukin-6) and white blood cells (monocyte / macrophag chemo-attractans protein-1), and adipose tissue regulatory peptides are very important influencing factors. , the so - called. the role of adipokines, whose effects are predominantly auto- and paracrine, and to a lesser extent endocrine. The role of these factors in obesity is increasing: an increase in adipogenesis (fat formation) results in an increase in their production, macrophage infiltration and low-grade chronic inflammation develop in adipose and liver tissue.
Several studies suggest that nuclear kappa light chain enhancer factor (NF-κB), a protein complex in activated macrophage cells, controls DNA activation. NF-κB is involved in the regulation of numerous genes, including cytokines, cell adhesion molecules, and genes that regulate apoptosis.
Prof. Sir Ravinder Maini
In 2017, Semmelweis University of Medicine awarded Sir Ravinder Maini, a world-renowned medical professor, with the highest international scientific recognition, the Semmelweis Budapest Award, for the development of biological therapies that revolutionized the research and treatment of inflammatory diseases.
Prof. Paul Clayton
On September 15, 2018, Professor Paul Clayton, who specializes in applied nutrition science, gave a lecture in Budapest.
His research activity is the design of multi-component nutrition science programs that can be used to prevent or reverse degenerative diseases (cancers, cardiovascular diseases, connective tissue diseases).
Prof. Osumi Josinori
Osumi Josinori received the Nobel Prize in Medicine in 2016, the results of which led to the ongoing revolution in autophagy research, as he discovered in yeast the genes whose products are needed for the most important pathway of autophagic degradation. The essence of autophagy is the dynamic balance of cellular recovery and degradation. It is a self-renewing process for the breakdown and recycling of cells' own materials and cellular organs, so the reduced function of autophagy contributes to the development of aging, cancer and neuronal cell death, such as Alzheimer's disease, Parkinson's disease, could significantly improve people’s quality of life.